Abstract
Fast-dissolving films (FDFs) were prepared from natural polysaccharides, such as pullulan, without heating, controlling the pH, or adding other materials. The release profiles of model drugs from the films were investigated. In the absence of a drug, the casting method and subsequent evaporation of the solvent resulted in the polysaccharide forming a circular film. The presence of drugs (both their type and concentration) affected film formation. The thickness of the film was controllable by adjusting the concentration of the polysaccharide, and regular unevenness was observed on the surface of 2% pullulan film. All films prepared with polysaccharides readily swelled in dissolution medium, released the incorporated compound, and subsequently disintegrated. The release of dexamethasone from the films was complete after 15 min, although this release rate was slightly slower than that of pilocarpine or lidocaine. Therefore, FDFs prepared from polysaccharides could be promising candidates as oral dosage forms containing drugs, and would be expected to show drug dissolution in the oral cavity.
Highlights
Numerous oral disintegration (OD) dosage forms have been developed, with tablets taken with water being the most widely utilized
To form films by the casting method, a polysaccharide solution containing a drug is prepared without heating and poured into a Petri dish
In the absence of drugs, 2–8% PUL, 1–3% low molecular ALG (L-ALG), 2% chondroitin sulfate (CHS) or 0.5% BSP formed a circular film about 5 cm in diameter after evaporation of the solvent
Summary
Numerous oral disintegration (OD) dosage forms have been developed, with tablets taken with water being the most widely utilized. The drug and the insoluble components, such as the disintegrated material incorporated in the OD tablet, remain on or around the tongue This dosage form, may not be easy to swallow, so the development of new forms for patients who have difficulty swallowing regular tablets is desirable. Natural polysaccharides and polypeptides have been studied as materials for food or dosage forms [6,7,8]. These polymers are utilized for film preparation; for example, agar and gelatin are popular because of their safety and ready supply. When a film dosage form is prepared with such polysaccharides, incorporated active compounds such as drugs are exposed in the environment. The release profile of each compound from the film dosage form was investigated
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