Abstract
The aim of this study was to prepare matrix beads made of enteric polymer, Eudragit® L, metronidazole and various amounts of cetyl alcohol (0, 0.1 and 1%). Eudragit® L, metronidazole and cetyl alcohol were dissolved in acetone and then extruded into dichloromethane. The influence of amount of cetyl alcohol on floating and drug release behavior of matrix beads of Eudragit® L was investigated. The results showed that, after extruding, cetyl alcohol dissolved out from the beads already formed, resulting in a porous structure. Thus, the beads can float in simulated gastric fluid for more than 8 hours. Different amounts of cetyl alcohol had a slight effect on the drug release. However, the increased amount of cetyl alcohol in the formulations significantly sustained the drug release while the beads remained floating. The results suggest that Eudragit® L beads could be used as a carrier for intragastric floating drug delivery.
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