Abstract
We explored the utility of poly(vinylalcohol) (PVA) film as a pharmaceutical transdermal carrier of erythromycin (EM) for the treatment of acne. EM-loaded PVA films were manufactured using PVA solution containing different amounts of EM in the presence or absence of various additives. Among the additives tested (glycerin, PEG, Tween80, CCT oil, and carboxymethylcellulose [CMC]), glycerin and PEG were suitable for the preparation of EMloaded PVA films. Several additives controlled the characteristic endothermic peaks of PVA and EM. Permeation of EM into the skin was measured using the prepared PVA films loaded with different EM concentrations and additives. EM from the EM-loaded PVA films showed sustained release behavior, and altering the amount of EM loaded and the additive allowed us to control the amount of EM released from these films. In conclusion, the PV films described here can serve as pharmaceutical transdermal carriers for sustained EM release.
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