Abstract
An easy and efficient one-pot reaction from readily available methylcyclopropanone acetal (2 S)- 4b gave the spirophosphonates 8a– b with excellent diastereoselectivity. These phosphonates, after catalytic hydrogenolysis and hydrolysis, furnished the enantiomerically pure (1 S,2 S)-1-amino-2-methylcyclopropanephosphonic acid 3b (analogue of (1 R,2 S)- allo-norcoronamic acid).
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