Abstract
Guaco (Mikania glomerata Sprengel) syrup is one of the most popular herbal medicines used to treat the symptoms of asthmatic bronchitis, cough and hoarseness. The coumarin 2H-1-benzopyran-2-one, is one of the major constituents of Guaco and contributes to its pharmacological effects. The pharmaceutical capsule form of dry extract of Guaco is recommended by the Brazilian Program of Medicinal Plants and Herbal Medicines and used in primary health care. In order to identify a new protocol to obtain the raw material for Guaco capsule production we evaluated two methods, including a freeze-drying process (lyophilization) and the spray-dryer technique, as well as the use of two adjuvants, Maltodextrins and Aerosil®, in different concentrations. The coumarin levels of the dried extracts were analyzed by UV-spectrophotometry and HPLC-UV/DAD. The adjuvant Aerosil® 8% showed better dry powder physical appearance. Lyophilization was observed to be the best process to obtain the dry extract of Guaco based on the measured coumarin levels.
Highlights
Mikania glomerata Sprengel, popularly known as Guaco, is a plant from the Asteraceae family with medicinal properties
In Brazil there are 512 registered phytotherapeutic drugs, of which more than 70% are presented as solid pharmaceutical capsule forms [4]
In this work we evaluated two adjuvants, Aerosil® and Maltodextrin, in preparing Guaco dry extracts using the spray drying and lyophilization processes to identify the best process for producing a dry extract with a high coumarin level
Summary
Mikania glomerata Sprengel, popularly known as Guaco, is a plant from the Asteraceae family with medicinal properties. Guaco is used as an effective natural bronchodilator, expectorant and cough suppressant in Brazilian herbal medicine. Guaco capsules is another pharmaceutical form produced from dry extract that appears in the list of phytotherapeutic drugs of interest of the Unified Health System (SUS) of Brazil [4]. Spraydrying is defined as the transformation of liquid state feed into a dried particulate form This is achieved by atomizing the fluid into a drying chamber, where the liquid droplets are passed through a hot-air stream. This technique is suitable for heat-sensitive products. The purpose was to identify the best method that provides the highest coumarin recovery level to generate the raw material for the production of the herbal medicine in solid form
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