Preparation of Dimethyl(4-nitro- and 4-chloro-benzyl)alkyl ammonium Chloride and their Physico-chemical, Antibacterial and Antifungous Properties

Abstract

The quaternary salts from N, N-dimethylalkyl-amines (R: dodecyl, hexadecyl and octadecyl)and 4-nitro- or 4-chloro-benzylchloride were prepared and their physico-chemical, antibacterial and antifungous properties were studied. The results obtained were as follows.(1) 4-Chloro-derivatives were supetior to 4-nitro-derivatives in such surface active properties as lowering of surfae tension, emulsifying of liquid paraMn and wetting of cloth.(2) The long alkyl chain derivatives were more powerful in lowering of surface tension, increasing of 'a' mmounts of solubilized Orange OT, emulsifying and wetting as compared with the short chain'derivatives.(3) A linear telationship Was observed between alkyl chain length and log CMC for a homologous series.(4) The growth retardati6n by the homologous compounds for mildew became progressively greater as. the carbon number of straight chain decreased.(5) The substituents, chloro and nitro group on benzene ring decreased antibacteria aRd antimildew actions against our expectations.