Abstract
Hydrogels, possessing high biocompatibility and adaptability to biological tissue, show great usability in medical applications. In this research, a series of novel cross-linked chitosan quaternary ammonium salt loading with gentamicin sulfate (CTMCSG) hydrogel films with different cross-linking degrees were successfully obtained by the reaction of chitosan quaternary ammonium salt (TMCS) and epichlorohydrin. Fourier transform infrared spectroscopy (FTIR), thermal analysis, and scanning electron microscope (SEM) were used to characterize the chemical structure and surface morphology of CTMCSG hydrogel films. The physicochemical property, gentamicin sulphate release behavior, cytotoxicity, and antibacterial activity of the CTMCSG against Escherichia coli and Staphylococcus aureus were determined. Experimental results demonstrated that CTMCSG hydrogel films exhibited good water stability, thermal stability, drug release capacity, as well as antibacterial property. The inhibition zone of CTMCSG hydrogel films against Escherichia coli and Staphylococcus aureus could be up to about 30 mm. Specifically, the increases in maximum decomposition temperature, mechanical property, water content, swelling degree, and a reduction in water vapor permeability of the hydrogel films were observed as the amount of the cross-linking agent increased. The results indicated that the CTMCSG-4 hydrogel film with an interesting physicochemical property, admirable antibacterial activity, and slight cytotoxicity showed the potential value as excellent antibacterial wound dressing.
Highlights
The skin is an important organ that maintains the osmotic balance of the body and protects the organism from environmental factors, and its integrity is very critical [1,2].As the first protective barrier against a harsh environment, skin inevitably causes trauma. the skin has a certain self-healing ability, the side effects such as inflammation and secondary damage accompanying the long-term repair process make it of great demand in designing and developing clinical wound dressings [3,4]
The results showed that the optimized hydrogel film could be used for drug delivery of wound dressing [13]
Novel CTMCSG hydrogel films with different cross-linking degrees were successfully prepared via the reaction of trimethyl chitosan (TMCS) and epichlorohydrin
Summary
The skin is an important organ that maintains the osmotic balance of the body and protects the organism from environmental factors, and its integrity is very critical [1,2].As the first protective barrier against a harsh environment, skin inevitably causes trauma. the skin has a certain self-healing ability, the side effects such as inflammation and secondary damage accompanying the long-term repair process make it of great demand in designing and developing clinical wound dressings [3,4]. Hydrogels have been regarded as notable candidates in wound dressings for drug delivery applications, owning to their good biocompatibility [10,11,12]. Zhang et al had successfully obtained the GMs/CMCS-OG composite hydrogels loaded with drugs. These composite hydrogels displayed fast gelation time, good stability, high mechanical properties, as well as strong antibacterial activity, which had potential for wide application in drug delivery and the anti-bacterial environment [8]. The results showed that the optimized hydrogel film could be used for drug delivery of wound dressing [13]. Hydrogel wound dressing is an ideal choice for wound treatment
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