Abstract
• The peptide from zein was glycosylated with d -glucosamine as an acyl acceptor by transglutaminase. • Glycosylation of the peptide increased its alcohol dehydrogenase activation rate. • The glycopeptides exhibited resistibility to gastrointestinal digestion. • The glycopeptides treatment at 250 mg/kg·bw alleviated alcohol-induced liver injury in rats. New glycosylated zein peptides (GZP) were produced by transglutaminase-induced d -glucosamine conjugation onto zein peptides. GZP’s antagonistic effects on alcohol-induced liver injury in rats were evaluated. Compared with the alcohol model group, GZP (250 mg/kg·bw) remarkably increased alcohol dehydrogenase, acetaldehyde dehydrogenase, endogenous antioxidant enzymes activities, and GSH levels in liver, decreased serum triacylglycerol, tumor necrosis factor-α, liver malonaldehyde, reactive oxygen species, and lipopolysaccharide (LPS) levels, and significantly reversed pathological changes in liver tissues. These results indicate that low-dose GZP administration can alleviate alcohol-induced liver injury by accelerating alcohol metabolism, reversing hepatic redox status, and attenuating LPS-mediated inflammation responses. GZP is a potential alcohol metabolism promoter and liver-protective agent.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
