Abstract
By suspension polymerization using styrene, divinylbenzene, and synthetic poly(ethylene glycol) (PEG) macromonomers, we have prepared core-shell-type resins that have a highly crosslinked polystyrene core and a PEG shell. The PEG macromonomer, which has a vinyl group and an amino group at each terminal, plays a role as a stabilizer in the suspension polymerization system. All the resins were of the bead type with a diameter of 38-150 μm. The loading capacities of the amino groups were 0.1-1.0 mmol.(g resin) -1 and the thickness of the PEG shell 2-4 μm, which was verified by cross-sectioned views of the fluorescamine-coupled beads. During coupling of amino acids in solid-phase peptide synthesis, the resin showed better yields than TentaGel resin, especially during the first coupling step. In the enzymatic cleavage reaction, the resin-bound peptides were shaved about 5-10 times more than TentaGel resin.
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