Preparation of components of ultrasonic extract of ginkgo biloba, physico-chemical and pharmacological analysis and molecular design

Abstract

The main task arising during the processing of medicinal plant raw materials is the intensification of extraction processes in order to maximize the extraction of groups of biologically active substances. It is of interest to obtain an extract and conduct molecular modeling in order to predict the biological activity of the components of the ginkgo biloba phytocomplex. The range of dosage forms obtained on the basis of dry extract is small, despite the wide range of pharmacological activity. The aim of the study is to optimize the method of obtaining alcohol extract, with the possibility of including it in various dosage forms. Physico-chemical analysis: Confirmation of the alleged pharmacological activity by the method of molecular modeling. Materials and Methods: Ultrasonic extraction, spectrophotometry in the ultraviolet region. Pharmacological studies by modeling cerebral ischemia using simultaneous bilateral occlusion of the common carotid arteries. Changing the speed of cerebral blood flow by Dopplerography. Results and Discussion. Liquid extract of ginkgo bilobar leaves was obtained by ultrasonic extraction. The calculation of the electronic structure and quantum-chemical descriptors of ginkgolide B. was carried out. The assessment of specific pharmacological activity was carried out. Conclusion: The ultrasonic method of extraction of ginkgo biloba leaves was applied. The predicted biological activity of the obtained phytocomplex was confirmed by methods of molecular modeling and experimentally.