Abstract
Objective: A simple formulation of cold cream from methanolic extract Caralluma adscendens var. attenuata (MECA) and their antimicrobial activity was tested against various clinical pathogens, namely, Escherichia coli, methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus faecium, and Candida albicans. 
 Methods: Methanol extract of these plant extract was prepared by the Soxhlet method. We analyzed phytochemical nature of theses plant, and subsequently, a cream was formulated cold-cream C. adscendens var. attenuata (FCA) different concentration such as FCA 50 mg, FCA 100 mg, and FCA 200 mg. In the present study, aimed to the antimicrobial activity of cold cream was measured by agar well diffusion method, and standard antibiotic Neosporin (market available) cream was used as positive control and dummy cold cream (without-MECA) were used as the negative control.
 Results: Phytochemical screening showed that the plant extracts were found a rich source of secondary metabolites. For more, the efficacy of cold cream from MECA extracts to against the clinical pathogen. Positive control Neosporin and 200 mg FCA cream was a highly significant difference in the zone of inhibition when compared to dummy cream. The 200 mg FCA was activity against Escherichia coli, methicillin-resistant Staphylococcus aureus, vancomycin-resistant E. faecium, and C. albicans highly significantly difference (p<0.05) compared FCA 50 mg and FAC 100 mg creams.
 Conclusion: The results from this study suggested that the cold cream form base of MECA crude had antimicrobial activity in the different clinical pathogen. They could be used as an alternative source to conventional antimicrobial agents for the treatment of pathological infection.
Highlights
Every plant possesses medicinal properties, in today’s context of medical field plants, the contribution is very essential, and most of the countries had interested to that ancient medicinal plants have reinvestigate to the discovery of active compounds and it is too established for disease curative [1]
The purpose of this study is to evaluate the formulated cold cream of antimicrobial activity against Escherichia coli, methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus faecium (VREF), and Candida albicans an under the control of laboratory condition
Characterization of phytocompounds and creams formulation The MECA crude possesses a mixture of phytocompounds that include alkaloids, carbohydrates, flavonoids, steroids, terpenoids, phenols, glycosides, tannins, and phlobatannins Table 2
Summary
Every plant possesses medicinal properties, in today’s context of medical field plants, the contribution is very essential, and most of the countries had interested to that ancient medicinal plants have reinvestigate to the discovery of active compounds and it is too established for disease curative [1]. Diseases are more abundant in the world; diseases causing by the agents called pathogens such as bacteria, fungi, and virus. These pathogens induced diseases by human being were divided that mild; severe infection; and death [2]. Natural products of phytocompounds have the potential to boost resistant the host-pathogen, and it possesses the antibacterial, antifungal properties [5]. We in this study were examined the phytoconstituent nature of this plant using qualitative analysis, and we formulated cold cream by methanolic extract Caralluma adscendens var. The purpose of this study is to evaluate the formulated cold cream of antimicrobial activity against Escherichia coli, methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus faecium (VREF), and Candida albicans an under the control of laboratory condition
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