Abstract
A preparation of chitosan-based nanofiber mats loaded with Soluplus as a novel carrier polymer was carried out. Soluplus, a water-soluble amphiphilic copolymer, was added to provide a nanofiber structure that will be useful in applications as drug delivery system. In this study, a mixture of chitosan, polyethylene oxide (PEO), and Soluplus micelles was electrospun into nanofibers and characterized using SEM to observe the fiber morphology. Rhodamine (Rh) was used as a model molecule trapped inside Soluplus micelles. The results showed that chitosan-based nanofiber mats were successfully realized by electrospinning of the chitosan/PEO polymer blend solution at a ratio of 3:2 with 4 wt% total polymer concentration. The optimum electrospinning parameters to obtain the nanofibers were at 30 kV electrical potential, 0.2 ml/hour feed rate, and 30 cm distance between the needle tip and the collector. The addition of Soluplus at four times greater critical micelles concentration (CMC) was still able to provide smooth and bead-less nanofibers morphology. Nanofiber mats with Rh-Soluplus have an average fiber diameter of 56 nm, a slightly thinner than the nanofibers with chitosan/PEO alone (63 nm). A preliminary study of Rh release from Soluplus micelles, as well as from Soluplus loaded in the nanofiber mats, showed slower release of Rh from Soluplus loaded in the nanofiber mats compared to the free Soluplus.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.