Abstract
A new 6-step process was developed for the synthesis of radiolabeled metosulam, a broadleaf post emergent herbicide being commercialized by DowElanco for use in small grains. Each step of the process can be accomplished in >80% yield thereby making the process a convenient and efficient route for the preparation of both radiolabeled and unlabeled samples of metosulam. A significant improvement was made in the coupling of the silylaniline with the sulfonyl chloride over the previously reported procedure which represents a key step in the process.
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