Abstract
In this work, the complex of borneol–methyl-β-cyclodextrin was prepared both by supercritical carbon dioxide processing and by the sealed heating treatment at mild pressure and temperature. An amorphous complex was obtained by the sealed heating treatment. A crystalline inclusion complex was obtained by the supercritical carbon dioxide processing. The crystalline complex is more stable than the amorphous complex. The apparent aqueous solubility of borneol could be enhanced about 70 times by complexation with methyl-β-cyclodextrin. In this work, a 1:1 crystalline inclusion complex between borneol and methyl-β-cyclodextrin was obtained by supercritical carbon dioxide processing at temperature about 100 °C and pressure about 100 bar. This inclusion complex is more stable than the amorphous complex prepared by the sealed heating method. The apparent aqueous solubility of borneol could be enhanced about 70 times by complexation with methyl-β-cyclodextrin. The possible complex structure is shown below:
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Journal of Inclusion Phenomena and Macrocyclic Chemistry
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
