Preparation of bio-composite hydrogel of hydroxyapatite based using gamma irradiation for artificial bone

Abstract

The aim of this study is to prepare bio nano-hydroxyapatite based biomaterial for artificial bone using gamma-γ. Preparation of composite hydrogel bio nano-hydroxyapatite based on artificial bone has been carried out via gamma irradiation techniques. The PVA-HAp viscose solutions were prepared using different ratios of HAp (15-30%) with a single PVA solution concentration (20 %) mixed strongly until homogenous. The prepared PVA-HA solution was molded, freeze-thaw to be composites and irradiated using gamma rays (0-20 kGy). The composites were measured its mechanical properties and biodegradation. Surface micrographs of composites were measured using Scanning Electron Microscopy (SEM). The results showed that at optimum conditions (20% PVA-30%,HAp, irradiation dose 20 kGy), the physical appearances of composite more flexible and strong with tensile strength were 1.003 MPa and the elongation at break was 372.33%. With increasing irradiation and HAp content up to 30%, the biodegradation of composite decreased. From SEM measurement the pore sizes of the composite were heterogeneous. PVA-HAp composites prepared using gamma irradiation can be considered as a candidate for biomaterial.