Preparation of Bentonite Clay/TiO2 Nanocomposites Surface as Drug Carrier: In-vitro Release Study of Chloramphenicol Drug

Abstract

The delivery of pharmaceuticals via nanocomposites has become a fascinating area of study in recent years, with applications in the development of tools and the treatment of infections and cancer. The porous properties of titanium dioxide and clay nanocomposites play a key role in the targeted delivery system. So, the large surface area and porous volume have more interest in the delivery of drugs and their loading. In this study, bentonite clay and titanium dioxide (TiO2) nanocomposites were synthesized by a hydrothermal method to guide infections and drugs. The composites of nanocomposites were used by the adsorption technique as loading drugs and studied for their ability to deliver drugs. It was confirmed that titanium oxide was added to the bentonite clay through the EDX and XRD. Sharp diffraction values were observed by the X-ray spectrum for clay and titanium oxide and less intensity for the superimposed (TiO2/bentonite), While it was found that EDX spreads the titanium and other ions. The thermal stability of the composite (TiO2/bentonite) was increased after adding titanium dioxide nanoparticles. The removal rate of chloramphenicol was higher in the base media, reaching 98% for both bentonite and TiO2/bentonite. An examination of the release rate of the drug was carried out by bentonite clay and TiO2/bentonite in the stomach and blood media, and the percentage of release was 26.6 and 5% in pH 1.2 and 7.5 for bentonite and 54.6 and 23.6% in pH 1.2 and 7.5, respectively, for TiO2/bentonite.