Preparation of anti-bacterial cellulose fiber via electrospinning and crosslinking with β-cyclodextrin

Youngwoong Kang,Hyoung Joo Kim,Younghan Song,Hyungsup Kim,Yong Keun Choi

doi:10.1186/s40691-015-0036-7

Abstract

AbstractIn the study, we successfully produced electrospun cellulose fibers crosslinked with β-CD. For electrospinning, cellulose was dissolve in 1-ethyl-3-methylimidazolium acetate and DMF was added to the prepared solution for better spinnability. The prepared cellulose fiber was immersed in the solution containing β-CD, crosslinking agent and sodium hypophosphite. In order to understand the effect of a crosslinking agent, two different types of the agents, BTCA (1,2,3,4-butanetetracarboxylic acid) and citric acid with various concentrations were used for cross-linking. The crosslinking degree was increased with the concentration of the crosslinking agents, for the both agents. The cross-linked web changed into membrane like morphology when the concentration of the cross-linking agent was higher than 5 wt%. The concentration of crosslinking agent also gave influence on the crystallinity, the thermal property and the antibacterial activity of fibers. Due to the cross-linking the crystallinity was decreased. The cross-linked fiber showed selective bacterial behavior according to the bacterial strain and the cross-linking agent.

Highlights

Cyclodextrins (CDs) are doughnut-shaped oligosaccharides consisting of α(1,4)-linked glucopyranose
FT‐IR spectroscopy Figure 1 shows the FT-IR spectra of the cellulose fibers before and after β-CD crosslinking
For the case of BTCA, the peak was considerably increased with the acid concentration and was larger comparing to the citric acid case at higher concentration

Summary

Introduction

Cyclodextrins (CDs) are doughnut-shaped oligosaccharides consisting of α(1,4)-linked glucopyranose. Due to their amphiphilicity, CDs are expected to be applied in many areas such as drug delivery, chromatography, selective removal and solubility enhancement (Araki and Ito 2007; Del Valle 2004; Giuffrida et al 2006; Hedges 1998; Naidoo et al 2004; Szejtli 1998). Three of the most important cyclodextrins are α-, β-, and γ-CDs which are consisting of 6, 7 and 8 glucose units, respectively. Sun et al (2011) studied the in vitro antibacterial activity of cyclodextrin-drug complexes using β-cyclodextrin and 2-hydroxypropyl β-cyclodextrin. The complexation of the antibacterial drug with the CDs improved the antibacterial activity by steady-state

Methods

Results

Conclusion