Abstract
AbstractIn this study, it was aimed to prepare prolonged action microcapsules of acetaminophen with short biological half-life by a non-solvent addition method which is one of the conservation-phase separation techniques.For this purpose, the three different particle size ranges of acetaminophen (0.088–0.177 mn, 0.250–0.354 mn, 0.420–0.500 mn) were used. The solution of polyisobuthylene in cyclohexane as a non-solvent and Eudragit RS and Eudragit RL as coating polymers were also used. The prepared mi crosapsules were compressed by a hydraulic press using different types of direct tableting agents such as Ludipress, Avicel PH 101 and Lactose EP D 30. Dissolution rates of each tablet containing 160 mg of microencapsulated acetaminophen were examined by continuous flow-through cell methodThe results of this study showed that the release rate of drug from microcapsules prepared with Eudragit RS was lower than that of microcapsules prepared with Eudragit RL. However different particle size ranges of drug didn'...
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