Abstract
In this paper, in order to take advantage of the combination between magnetic nano-Fe3O4 and surface modifier, a pH-sensitive drug delivery system that could effectively deliver doxorubicin (DOX) to tumor tissue was constructed. The novel drug delivery system named Fe3O4-TIPTS-g-(PEI-co-PEG) was prepared through three steps. The first step, a surface modifier with the thiol group, thiohydrazide-iminopropyltriethoxysilane surface modifier (named TIPTS), was synthesized for the first time. The second step, Fe3O4-TIPTS was synthesized by treating nano-Fe3O4 with TIPTS. The last step, Fe3O4-TIPTS-g-(PEI-co-PEG) was synthesized in the presence of the Fe3O4-TIPTS, polyethyleneimine (PEI), and polyethylene glycol (PEG) by mercapto-initiated radical polymerization. Among them, magnetic nanoparticles (MNPs) were used as magnetically responsive carriers, PEG was the surface-modifying compound, and PEI was the drug loading site which primary amine reacts with doxorubicin (DOX). Targeted nanoparticles were considerably stabilize in various physiological solutions and exhibited pH-sensitive performance in drug release. Thence, Fe3O4-TIPTS-g-(PEI-co-PEG) is a promising nanocarrier for targeting tumor therapy.
Highlights
In the last few decades, the incidence and mortality of malignancy increased year by year, and it has become the leading cause of death in humans
Nano-Fe3O4 was modified by the mercaptosilane surface modifier TIPTS, and block copolymer poly(ethylene glycolco-ethyleneimine) grafted Fe3O4 to obtain Fe3O4-TIPTS-g(PEI-co-polyethylene glycol (PEG))
The nano-Fe3O4 was a core of Fe3O4TIPTS-g-(PEI-co-PEG) which possesses the targeted function
Summary
In the last few decades, the incidence and mortality of malignancy increased year by year, and it has become the leading cause of death in humans. Among different types of nanomaterials, Fe3O4 nanoparticles is one kind of MNPs that have shown great promise as novel delivery systems and theranostics for personalized medicine due to their shape controllability and large specific surface area. Most importantly, their unique optical, electrical, and superparamagnetic properties give potential imaging development, targeted delivery, and synergistic drug therapy, suitable for drug delivery in cells [5]. Naked Fe3O4 NPs are easy to aggregate and oxidize and were often coated by hydrophilic materials and biocompatible polymers for targeted drug delivery [6,7,8]
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