Abstract
A one-pot, two-step method for the preparation of degradable PEG is here presented. The full process addresses the requirements imposed by green chemistry and involves the use of a single and nontoxic non-eutectic mixture of organocatalysts. The strategy relies on the polycondensation of PEG800 after its functionalization by bio-derived 5-membered γ-butyrolactone.
Highlights
A one-pot, two-step method for the preparation of degradable polyethylene glycol (PEG) is here presented
The effects of surface coverage by the hydrophilic, biocompatible and FDA-approved PEG are mainly characterized by nonrecognition by the immune system and a reduced tendency of nanoparticles to aggregate by steric stabilization.[2]
We provide a complete description of PEG polycondensates synthesis in solvent-free condition respecting the workable de nition of green chemistry
Summary
A one-pot, two-step method for the preparation of degradable PEG is here presented. The full process addresses the requirements imposed by green chemistry and involves the use of a single and nontoxic non-eutectic mixture of organocatalysts. Preparation of a mimetic and degradable poly(ethylene glycol) by a non-eutectic mixture of organocatalysts (NEMO) via a one-pot two-step process†‡
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