Abstract
A novel hyaluronic acid (HA)-based hydrogel was prepared through polyion complex (PIC) formation between cationic polylactide (PLA)-based microspheres (MS+) and hyaluronic acid (HA−) as an anionic polyelectrolyte. The MS+ and HA formed a biodegradable PIC hydrogel (HA−/MS+) when mixed in aqueous media. The swelling behavior and mechanical properties of the PIC hydrogel could be controlled by changing the charge ratio between HA− and MS+. In addition, the HA−/MS+ PIC hydrogel resulted in a lower inflammatory response compared with a collagen hydrogel in vivo.
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