Preparation of a composite fibrous membrane loaded with mesalazine and metronidazole by interlaced electrospinning

Abstract

Novel composite fibrous membranes loaded with mesalazine and metronidazole were fabricated via interlaced electrospinning. The fibers were characterized by scanning electron microscopy and FTIR transmission spectra techniques. These characterizations were performed in the aim of optimizing the experimental conditions which allowed us to obtain good morphology of fibrous membrane loaded drugs. The in vitro release experiments revealed that mesalazine and metronidazole were released continuously from the loaded drug fibrous membrane. The fibrous membrane-loaded drugs also showed excellent stability. Compared to those of other drug delivery systems, the main advantage of these two fibrous membrane-loaded drugs is that they can be directly implanted as a lesion after surgery to inhibit recurrence in Crohn's disease.