Abstract
AbstractAn easy synthesis of 6‐methoxy equilenin derivatives is described starting with 7α‐bromo‐6‐ketoestradiol 17‐acetate (Va). The resulting 6‐hydroxyequilenin dimethyl ether (VIIIa) was transformed into 17β‐acetamido‐3,6‐dimethoxy‐1,3,5(10), 6,8‐estrapentaene (IXd), the racemic form (XIIId) of which was made from the totally synthetic compounds (Xa) and (XIa), Also the D‐antipode (XXI) of 3,6‐dimethoxy‐176 ‐acetyl‐1,3,5(10), 6,8‐estrapentaene was synthesized from (VIIIa) and compared with its racemic form (XIa). Treatment of the estrapentaene (VIb) with sodium and isopropanol afforded the ketone (XVIb) which was further reduced to the triol (XVII).
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