Abstract

Abstract The Nazarov electrocyclization has become a versatile method for the synthesis of cyclopentenones with a broad range of substitution patterns, with excellent potential as building blocks for complex molecule synthesis. The article describes the synthesis and use of dienyl diketones as substrates in Nazarov cyclizations, initiated by 1,6‐conjugate addition of an amine or malonate nucleophile. A three‐step protocol is employed to prepare the dienyl diketones, and the cyclization produces 5‐hydroxycyclopentenones in high yields.

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