Preparation of 2-amino-2′-hydroxy-1,1′-binaphthyl and N-arylated 2-amino-1,1′-binaphthyl derivatives via palladium-catalyzed amination

Abstract

Palladium-catalyzed amination reactions were carried out with 2-triflato-2′-(4-methoxybenzyloxy)-1,1′-binaphthyl ( 5) and benzophenone imine followed by hydrolysis of the imine and hydrogenolysis of the benzyl protecting group to afford 2-amino-2′-hydroxy-1,1′-binaphthyl ( 1). Arylamines were also coupled successfully with 5 under similar conditions.