Abstract
Starting from 2, 6-dichlorobenzonitrile, 2, 6-difluoroaniline was prepared in three steps. Thus, the dichlorobenzonitrile was fluorinated to 2, 6-difluorobenzonitrile by a halogen exchange. This product was partially hydrolyzed into 2, 6-difluorobenzamide, which was subsequently converted into 2, 6-difluoroaniline by the Hofmann reaction. The overall yield of the difluoroaniline was 5560%.2, 6-Difluorobenzoic acid and methyl 2, 6-difluorophenylcarbamate were also prepared from those intermediates.
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