Abstract
AbstractPreparation of radiolabeled [125I]‐N,N′‐bis(2,3‐dihydroxypropyl)‐5‐(3‐hydroxy‐2‐oxo‐1‐piperidinyl)‐2,4,6‐ triiodo‐1,3‐benzenedicarboxamide, ([125I]‐3H2‐iopiperidol‐A), a nonionic radiographic contrast agent, was achieved by HAuCl4 mediated exchange radioiodination. [125I]‐Iopiperidol‐A was isolated by reversed‐ phase HPLC in 83% radiochemical yield. The radiochemical purity of isolated [125I]‐3H2‐iopiperidol‐A was 98.7% and the specific activity was 6.6 mCi/μmol. The role of HAuCl4 in facilitating exchange radioiodination of 3H2‐iopiperidol‐A, however, appears to be a complex process not limited to the production of electrophilic iodine ion.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Journal of Labelled Compounds and Radiopharmaceuticals
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
