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Abstract
Abstract Silica-supported Lewis acids are useful catalysts in conjunction with microwave irradiation for the synthesis of a range of alanine derivatives. Reaction of methyl α-acetamidoacrylate ( 1 ) with different heterocycles, such as furan ( 2 ), pyrrole ( 3 ), N -benzylpyrrole ( 4 ), indole ( 5 ) and pyrazole ( 6 ) and the carbocycle 1,3,5-trihydroxybenzene ( 7 ), led to several α-amino acid precursors.
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