Preparation «Karipain Scar» in a pediatric combustion unit

Abstract

Introduction. The existing problem of post-burn scar treatment is associated with diffculties in delivering enzyme preparations through the cicatricial tissue; so, it is stimulating searches for the preparations with proteolytic and anti-inflammatory effects which could penetrate deep into scar thickness. Such a preparation is the gel "Karipain Scar" (manufacturer LLC "Scientifc and production company "AS-COM", Moscow, Russian Federation), containing proteolytic enzymes and a transcutaneous conductor – titanium glycerosolvate aquacomplex in the form of a gel (trade name Tizol®, LLC "Society for Laboratory Research of Medicines", Ekaterinburg, Russian Federation). The article describes administration of this preparation in a pediatric combustion unit to treat post-burn pathological scars, including old scars , by applying the drug on scars and by electrodragging.Material and methods. The described technique is used one month after the wound healing. At the frst stage of the study, Karipain Scar was applied on the scar area twice a day to the patients of experimental group (20 children aged 4-16 years with scars on limbs, torso, and large joints). At the second stage, Karipain Scar gel was applied to 18 patients aged 4-16 with scars on limbs, torso, and joints using electrodragging. The scars were photographed once a week and assessed by the Vancouver Scar Scale (VSS).Results. At the frst stage , all participants of the experimental group reported less itching until its complete disappearance by the end of the second week and the decrease of scar height at the beginning of the second month of treatment. The scars turned pale by the end of the 2nd month. At the second stage, 100% of patients from the experimental group reported the improvement in scars since the 5th procedure. There was no signifcant difference between fresh and old scars. Karipain Scar gel was well-tolerated. There were no allergic reactions and complications.Conclusion. The conducted studies has confrmed the effectiveness of Karipain Scar gel for treating children with post-burn scars