Preparation, evaluation and optimization of solid lipid nanoparticles composed of pantoprazole

Abstract

Nanoparticles are a promising medication delivery method that can deliver drugs in a controlled and targeted manner. They're made to release the medicine in close proximity to the target tissue. Solid lipid nanoparticles (SLNs) are a new type of submicron-sized lipid emulsion in which solid lipid replaces liquid lipid (oil). The goal of this study was to create solid lipid nanoparticles (SLN) containing pantoprazole (a proton pump inhibitor) and improve the drug's entrapment efficiency in SLN. This was accomplished by integrating the medication into solvent-injection-prepared solid lipid nanoparticles (SLN). During formulation development, the component concentrations were optimized, and then the particles were characterized in terms of particle size, zeta potential, drug loading, percent drug entrapment, stability studies, and drug release behavior. There was no interaction between the medication and the excipients in FT-IR experiments. The improved formulation's percent EE, particle size, and drug content were found to be 91.88±1.38, 7.16±0.26µm and 97.20±1.46 respectively. F6 was shown to be the most promising formulation among all created formulations in this investigation. For 30 days, stability tests were conducted (F6) at refrigerated temperature (4.0±0.2°C), room temperature (25-28±2°C), and 45±1°C. The current project also aims to improve the formulation's pharmacological acceptability.
 Keywords: Solid lipid nanoparticles, Pantoprazole, Solvent-injection method, Entrapment efficiency