Preparation, evaluation, and identification of the biological, laser, and nanoscale activity and computational chemistry of some 3,2-dihydroquinozolin-4-on compounds derived from 4-aminotetrahydropyrane

Abstract

This research prepares heterocyclic compounds by the compound [G1] from the reaction of 2-chloroacetohydrazide with 4-amino-tetrahydropyrane in absolute ethanol with drops of triethylamine 3 (C2H5)N. Then the hydrozones [G7-G2] were prepared from the [G1] reactor with some substituted benzaldehyde in absolute ethanol using an acidic medium. Derivatives of 2,3-dihydroquinozoline 4-on ]G8-G13[ were prepared by the reaction of the hydrozones ]G2-G7[ with anthranlic acid using 4,2-dioxane as a solvent then adding sodium carbonate to get rid of the residual acid used. After purification of the product, the prepared compounds were characterized by some spectroscopic methods, such as infrared (IR), proton nuclear magnetic resonance (NMR) [1H and carbon NMR] 13C, as well as the study of the thermal stability of some 3,2-dihydroquinozolin 4 compounds using the laser, obtaining nanoparticles, determining their shapes and sizes, the computational chemistry of all the prepared compounds, in addition to identifying the melting and purity degrees of the prepared compounds following the course of the reactions by thin layer chromatography (TLC).