PREPARATION CHOLESTEROL AND EFFECTS OF CHOLESTEROL PARADOX: A REVIEW

Abstract

Cholesterol is the most significant sterol in mammals, which contributes to preserving plasma membrane fluidity and serves as a precursor of oxysterols, bile acids, and steroid hormones. Plasma membranes contain large amounts of cholesterol, which interacts with other molecules in the membrane in various ways. Cholesterol, one of the most significant structural elements, is regarded as a lipid-type molecule. It plays a crucial role in life, primarily in cell membranes and as a precursor to the biosynthesis of numerous steroid hormones in cell membranes. Cholesterol absorption is linked to recurrent cardiovascular events, and patients with higher cholesterol absorption experienced less of a statin's favourable effects. One of the essential and prevalent conditions that affect people's health worldwide is coronary artery disease (CAD), and its incidence has grown over time. The best predictor and moderator of coronary artery disease is the low-density lipoprotein cholesterol plasma level. Higher than lower HDL cholesterol levels were associated with a lower risk of major cardiovascular events. Contrarily in cholesterol paradox states, individuals with advanced HF often have low cholesterol, associated with a poor prognosis and hypercholesterolemia, a key risk factor for CAD. On average, patients with a total cholesterol level of 232 mg/dl had a 25% higher survival rate than those with a total cholesterol level of 193 mg/dl who were suffering from heart failure. A total cholesterol level under 200 mg/dl is generally preferred.