Abstract
Papaya leaves have been using for wound healing that contains flavonoids, saponins, phenolics, chymopapain, and papain enzymes. The aim of this research were preparation, characterization, and wound healing activity of papaya leaves extract on spray gel. Spray gel was formulated with variation of gelling agent such as carbopol 940, HPMC, gellan gum, and hydroxyethylcellulose. The spray gel were characterizated by organoleptic, pH, stickiness test, viscosity, homogeneity, weight, and wound healing activity in rats. The results showed were all of formula spray gel have brown and homogeneous, pH between 5,947-6,347 within pH range of skin, stickiness test between 1,92-8,12 s, viscosity between 880-1740 cPs. Papaya leaves extract on spray gel has wound healing activity in rats faster than extract and positive control that is 16 days. The wound healing of papaya leaves extract on spray gel exhibited significantly different (p<0,05) than negative control.
Highlights
Wound is damage or loss of body tissue due to factors such as trauma, temperature changes, chemicals, explosion, electric shock, or animal bites (Pusponegoro, 2005)
The purpose of this study are the preparation, characterization, and wound healing activity of papaya leaves extract on spray gel with a variation of gelling agents to show an effect on physical characteristics and wound healing activity
This study has developed a gel to spray formulation using gelling agents as an approach to increase papaya leaves extract on the wound skin and increase wound healing process
Summary
Wound is damage or loss of body tissue due to factors such as trauma, temperature changes, chemicals, explosion, electric shock, or animal bites (Pusponegoro, 2005). The wound healing process is influenced by fibroblast components. This component is a cell that exists in connective tissue that produces collagen precursor substances, elastic fibers, and reticular fibers (Marcovitch, 2005). Papaya leaves contain are flavonoids, phenolics, saponins, papain enzymes, and chymopapain that have the activity of wound healing. Flavonoids have antioxidant and inflammatory activity possible in the wound healing process. The ability of flavonoids in the wound healing process is to inhibit uncontrolled inflammation. Papain enzymes and chymopapain reported have antibacterial and anti-inflammation activities. Papain enzymes have potent anti-inflammatory activity that works with vitamin A, C, The development of topical pharmaceutical dosage forms in increasingly rapid, including gels, creams, and ointments. According to Suyudi (2014) the spray gel formulations required additional ingredients such as humectants, preservatives, and gelling agents
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
