Abstract
Prepared Tanshinone IIA lipid microspere and evaluated its physicochemical properties in vitro and pharmacodynamics properties in vivo. Particle size, zeta potential, entrapment efficiency, quantitative determination and stability of Tan-IIA-LM with different dilution medium were investigated respectively by Dynamic Light Scattering, HPLC and Sephadex G-50 Microcolumn, and osmotic pressure and solution pH of Tan-IIA-LM were measured to evaluate the preparation comprehensively. Further more, comparative study of protection on focal cerebral ischemia/reperfusion injury in rats between Tan-IIA-LM and STS was studied.The results showed that average particle size was 203nm, zeta potential was-36.10 mV, content was 0.8mg·mL-1, entrapment efficiency was 93% and the Tan-IIA-LM which was diluted by 0.9% sodium chloride injection and 5.0% glucose injection were stable within 6 hours. Tan-IIA-LM had obvious protection on focal cerebral ischemia/reperfusion injury in rats.
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