Abstract
Objective: Tween 80 has been used as a solvent for the extraction of phenolic compounds because this surfactant has both hydrophilic and hydrophobicproperties. Solid lipid nanoparticles (SLNs) have been developed to improve penetration through the skin layer. We investigated the efficacy of usingthe microwave-assisted micellar extraction (MAME) approach for extracting oxyresveratrol from Morus alba roots and also to develop an SLN lotion.Methods: The M. alba roots were extracted with Tween 80 in a microwave for 18 min, and the extract was used to develop SLN with differentconcentrations of glyceryl monostearate. The SLNs from M. alba root extracts were prepared by a high-speed homogenization technique (25,000 rpmfor 15 min). The SLNs produced were characterized as per particle size, polydispersity index (PDI), and zeta potential. The SLNs with the bestcharacteristics were used to formulate a lotion using a high-pressure homogenizer.Results: Extraction using MAME showed improved extraction efficiency. The oxyresveratrol concentration from the extract was 2.77%. The SLN with2.5% glyceryl monostearate showed the optimum result, with a particle size of 130.20 nm, a PDI of 0.278, and a zeta potential of −21.8 mV. The SLNlotion exhibited a particle size of 285.9 nm and a PDI of 0.360. The SLN lotion also had good penetration, with a flux of 4.70 μg cm−2/h.Conclusion: MAME is an efficient method for extracting oxyresveratrol from M. alba roots. The SLN with 2.5% glyceryl monostearate exhibited theoptimum characteristics, and the SLN lotion showed good characteristics, including skin penetration.
Highlights
The stability of the dosage form is essential because it can provide evidence of the quality of drug products over time in response to various environmental factors such as temperature, humidity, and light
Physical stability of the preparations can be enhanced by physical development, such as the use of solid lipid nanoparticles (SLNs) [3]
SLN is a type of nanoparticle of an active compound comprising a solid lipid dispersed in an aqueous medium in the presence of a surfactant as an emulsifier
Summary
The stability of the dosage form is essential because it can provide evidence of the quality of drug products over time in response to various environmental factors such as temperature, humidity, and light. The stability test of the preparation may determine the duration of use of a drug product and its recommended storage conditions [1]. The physical stability of the product is related to the physical form of the preparation such as sedimentation, creaming, flocculation, coalescence, and phase separation [2]. Physical stability of the preparations can be enhanced by physical development, such as the use of solid lipid nanoparticles (SLNs) [3]. SLN is a type of nanoparticle of an active compound comprising a solid lipid dispersed in an aqueous medium in the presence of a surfactant as an emulsifier. SLN can be applied in various types of preparations, one of which is a lotion. An SLN lotion can deliver active nature-identical compounds
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