Abstract
Curcumin (Cur) is an anti-inflammatory polyphenol that can be complexed with polymeric cyclodextrin (CD) to improve solubility and bioavailability. The aim of the present work was to prepare a CurCD hydrogel to treat inflammatory skin conditions. Epichlorohydrin-β-CD (EpiβCD) was used as polymeric CD. To characterize the binary system, solid-state and in-solution studies were performed. Afterwards, an experimental design was performed to optimize the hydrogel system. Finally, the CurEpiβCD hydrogel system was tested for anti-inflammatory activity using a HaCat psoriasis cell model. Co-grinded Cur/EpiβCD binary system showed a strong interaction and Curcumin solubility was much improved. Its combination with Pluronic® F-127/hyaluronate hydrogel demonstrated an improvement in release rate and Curcumin permeation. After testing its anti-inflammatory activity, the system showed a significant reduction in IL-6 levels. Hydrogel-containing CurEpiβCD complex is a great alternative to treat topical inflammatory diseases.
Highlights
Curcumin (Cur) is the main active ingredient of turmeric (Curcuma longa)
In order to evaluate the complexing and solubilizing abilities of EpiβCD towards Curcumin, phase solubility studies were performed in phosphate buffer pH 5
We demonstrated for the first time the anti-inflammatory properties of CurEpiβCD-Gel in an in vitro model of psoriasis, established using HaCaT keratinocytes treated with TNF-α
Summary
Curcumin (Cur) is the main active ingredient of turmeric (Curcuma longa). This spice has been used in some Asian countries as traditional medicine for multiple purposes, such as worm treatment, swelling, improving digestion, etc. Its anti-inflammatory activity derives from Curcumin capability to modulate TNF-α, IL-1β and IL-6 expressions and inhibit COX-2, NF-κB and MAPK pathways [2]. The phenolic OH is susceptible to reaction, losing a proton In both cases, when an oxidant agent reacts with Curcumin, the molecule loses a proton, creating a radical that is stabilized by delocalization [2,3]
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