Abstract
Silver nanoparticles (AgNPs) are gaining a great deal of attention in biomedical applications due to their unique physicochemical properties. In this study, green synthesis of AgNPs was developed using seaweed polysaccharide fucoidan. The AgNPs were further coated with chitosan to form an electrolyte complex on the surface. The developed chitosan–fucoidan complex-coated AgNPs were characterized using UV-visible spectroscopy, Fourier transform infrared spectroscopy (FT-IR), and transmission electron microscopy (TEM). FT-IR results suggested strong polyelectrolyte complexation between fucoidan and chitosan. The developed chitosan–fucoidan complex-coated AgNPs significantly inhibited microbial growth. Moreover, the AgNPs showed efficient anticancer activity in human cervical cancer cells (HeLa). This study demonstrated that chitosan–fucoidan complex-coated AgNPs hold high potential for food and cosmeceutical applications.
Highlights
Nanotechnology is gaining much attention in several fields, such as energy, medicine, and environmental areas [1,2,3]
dynamic light scattering (DLS) results shown in Figure 3A,B indicate that the average size of chitosan–fucoidan complex-coated AgNPs (73.1 nm) is larger than that of fucoidancoated AgNPs (53.1 nm)
Significant cytotoxicity was observed at the 50 μg/mL of concentration, The cytotoxicity of chitosan–fucoidan complex-coated AgNPs was assessed against human and the IC50 value was found to be around 35 μg/mL (Figure 7A)
Summary
Nanotechnology is gaining much attention in several fields, such as energy, medicine, and environmental areas [1,2,3]. Engineered metal nanoparticles can be produced in multiple ways, such as chemical synthesis [5] and biosynthesis methods [7]. Wei et al and Murugadoss et al developed AgNPs with chitosan [10] These polysaccharides were utilized as reducing agents to reduce silver ions to AgNPs, and as stabilizing agents. Several studies have suggested that chitosan–fucoidan polyelectrolyte/nanoparticles have great advantages in drug delivery [31,32,33,34,35,36,37,38,39] and tissue engineering [40,41,42] due to their efficient drug encapsulation and cellular uptake. Chitosan–fucoidan complex-coated AgNPs were synthesized and utilized for antimicrobial and anticancer activities.
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