Abstract
Poly(adipic anhydride-co-D,L-lactide) (P(AA-LA)) has been synthesized by ring-opening polymerization of adipic anhydride (AA) and D,L-lactide (LA) using stannous octoate as catalyst in bulk and in solution. The copolymers were characterized by IR, nuclear magnetic resonance, gel permeation chromatography and differential scanning calorimetry. The physical properties can be tailored by varying the copolymer compositions, and showed low glass transition temperature, melting temperature and good solubility in common solvents. In vitro tests showed that after rapid weight loss in the first day, a constant degradation rate was observed. The release profiles of model drugs, bovine serum albumin and norethindrone over 16 days followed closely that of the degradation of copolymers containing higher amounts of AA (AA > 64mol%), suggesting that the release mechanism was controlled predominantly by surface erosion. However, a large deviation from the close correlation of polymer degradation and drug release was observed for copolymers containing lower amounts of AA (< 30 mol%). These materials may be useful in protein delivery systems.
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