Abstract
Polymeric micelles have been shown to be promising carriers for drug delivery. However, the present developed micelle carriers are usually based on inert materials, and the potential influence on the body still needs to be further considered. In this work, we synthesized a kind of polymeric carrier based on hydrophobic long chain fatty alcohol (LCFA), which possesses beneficial biological properties for the human body. These polymeric carriers could self-assemble to form micelles with small sizes. Except for MPEG2k–C24, and MPEG2k–C26, other polymeric micelles showed good blood compatibility and high biosafety. In addition, MPEG2k–C28, MPEG2k–C30 and MPEG2k–C32 micelles could efficiently encapsulate paclitaxel (PTX) with about 10% drug loading content and >90% encapsulation efficiency. Overall, our prepared MPEG-LCFA conjugates may have potential clinical application prospects and deserve further research.
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