Abstract
A membrane of cationic starch-derivative/poly(vinyl alcohol) was prepared and utilized as a support to immobilize a β-cyclodextrin/curcumin inclusion complex. The resulting material (denote as β-CD/CUR-MBN) was characterized in detail by different techniques. In vitro experiments revealed that β-CD/CUR-MBN enables the controlling of the curcumin release process, which is guided by the relaxation of the polymer matrix. Moreover, cytotoxic assays were performed to investigate the effect of β-CD/CUR-MBN on two cancer cell lines (melanoma and glioblastoma). The results showed that the polymeric membrane exerts higher cytotoxicity against these cells than free curcumin. Also, β-CD/CUR-MBN exerted a prolonged cytotoxic effect (up to 96 h), even using a low concentration (50 μg mL−1), indicating that the curcumin in the polymeric membrane showed increased bioavailability under the tested condition. β-CD/CUR-MBN was non-cytotoxic against normal cells suggesting a specific action of this material against target cancer cells. The results reported here allow ranks β-CD/CUR-MBN as a promising biomaterial to act as a local drug delivery system to treat cancer.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: International Journal of Biological Macromolecules
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
