Abstract
Phlorotannins are a group of major polyphenol secondary metabolites found only in brown algae and are known for their bioactivities and multiple health benefits. However, they can be oxidized due to external factors and their bioavailability is low due to their low water solubility. In this study, the potential of utilizing nanoencapsulation with polyvinylpyrrolidone (PVP) to improve various activities of phlorotannins was explored. Phlorotannins encapsulated by PVP nanoparticles (PPNPS) with different loading ratios were prepared for characterization. Then, the PPNPS were evaluated for in vitro controlled release of phlorotannin, toxicity and antioxidant activities at the ratio of phlorotannin to PVP 1:8. The results indicated that the PPNPS showed a slow and sustained kinetic release of phlorotannin in simulated gastrointestinal fluids, they were non-toxic to HaCaT keratinocytes and they could reduce the generation of endogenous reactive oxygen species (ROS). Therefore, PPNPS have the potential to be a useful platform for the utilization of phlorotannin in both pharmaceutical and cosmetics industries.
Highlights
IntroductionResearch on bioactive substances originated from algae has increased rapidly
In recent years, research on bioactive substances originated from algae has increased rapidly.These compounds can serve as preservatives and antioxidant protectants in food and cosmetics, and show multiple health benefits [1]
In order to evaluate the stability of the PVP nanoparticles (PPNPS), the nanoparticles were prepared with different
Summary
Research on bioactive substances originated from algae has increased rapidly These compounds can serve as preservatives and antioxidant protectants in food and cosmetics, and show multiple health benefits [1]. Among these active compounds, polyphenolic phlorotannins, a group of complex molecular assemblages from the polymerization of phloroglucinol [2], represent a large class of well-characterized brown algae secondary metabolites [3]. Low water solubility of phlorotannin leads to low absorption in the gastrointestinal tract, which affects their bioavailability [13,14]
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