Preparation and use ofα-bromomono- and-bromobis-difluoromethoxyacetophenones in the synthesis of polymethyleneimidazoles with an angular nitrogen atom

Abstract

The synthesis of α-bromo-4-difluoromethoxy- and α-bromo-2,4-bis(difluoromethoxy)acetophenones has been carried out. Conditions have been studied for condensing the latter with cyclic tri- and tetramethylenamidinines and with pyridine-containing derivatives. A series of pyrrolo[1,2-a]imidazole and imidazo[2,1-a]pyridine derivatives containing difluoromethoxy groups has been synthesized.