Preparation and swelling studies of biocompatible hydrogel systems by using gamma radiation-induced polymerization

Abstract

Hydrogels with varying cross-linking densities and average molecular weights between two consecutive cross-links were prepared from the binary poly( N-vinyl-2-pyrrolidone)/water and ternary poly( N-vinyl-2-pyrrolidone)/water/K 2S 2O 8 systems by irradiation with γ rays at ambient temperature. Both hydrogel systems were employed for diffusion and swelling experiments in 0.1 g/100 ml Bovine Serum Albumin (BSA) solution at room temperature. Diffusion of BSA solution into hydrogels has been found to be of the Fickian type. The percent swelling, equilibrium swelling, initial rate of swelling, swelling rate of constant, equilibrium water/BSA content, and diffusion constant values were evaluated for PVP and PVP/K 2S 2O 8 hydrogel systems at 0.1 g/100 ml BSA solution.