Preparation and Sustained-Release Testing of Chitosan/Montmorillonite/Acetaminophen Microspheres

Abstract

Chitosan (CS) is an important slow-release carrier of drugs and fertilizers. The pure chitosan have poor performance, it should be added to a certain amount of crosslinking agents, emulsifiers and porogenic agents to improve the performance of it. The advantage of montmorillonite is no pollution and no toxicity, composite material filled in montmorillonite has an excellent mechanical properties. In this article, CS/MMT/ACAP drug-loading microsperes was prepared with the CS, ACAP and MMT as the main raw materials by emulsification-crosslinking method. Orthogonal experiment was designed to optimize the preparation process of the CS/MMT/ACAP drug-loading microspheres. FT-IR, XRD and SEM were applied to characterize the structure and morphology of microspheres. The sustained release effect of CS/MMT/ACAP microsphere was measured by sustained release measurement. The results show that the CS/MMT/ACAP drug-loading micropheres were successfully prepared by emulsification-crosslinking method. The microspheres assumed a good sphericity and a uniform particle size distribution; the drug-loading microspheres had good sustained release effect.