Preparation and study of dinuclear zinc(II) complex for the efficient hydrolysis of the phosphodiester linkage in a diribonucleotide

Abstract

A dinuclear zinc(II) complex with N,N,N′,N′-tetrakis[(2-pyridyl)methyl]-2-hydroxy-1,3-diaminopropane efficiently hydrolyses ApA [adenylyl(3′-5′)adenosine] at pH 7 and 50 °C; the complex can thus be regarded as a good artificial ribonuclease which effectively mimics enzyme active sites.