Abstract
Quercetin is a kind of flavonoid with important bioactivity, which is unstable. Quercetin liposomes were prepared to improve the stability of quercetin through a green thin-film dispersion method. We optimized the formulation of quercetin liposomes using response surface methodology. Results showed that the particle size and encapsulation efficiency(EE) of quercetin liposomes were 192.1 nm±3.24 nm and 65.82%±1.35%, respectively. Additionally, we evaluated the stability of quercetin and quercetin liposomes under different storage conditions. The results showed that light, temperature and metal ions had obvious effects on the stability of quercetin and quercetin liposomes. Meanwhile liposomes have ameliorative effects on the stability of quercetin.
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