Abstract
Tablets of glyceryl trinitrate were prepared by direct compression employing microcrystalline cellulose. These tablets were nonfriable and exhibited sublingual availability comparable to commercially available hypodermic tablets. Compressed tablets of microcrystalline cellulose showed only slight loss of glyceryl trinitrate at 50° when compared to commercial hypodermic tablets which lost up to 95 per cent. Glyceryl trinitrate formulated in a directly compressed sublingual tablet of microcrystalline cellulose presents an aesthetic stable dosage form which is a marked improvement over presently available glyceryl trinitrate dosage forms.
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