Preparation and Properties of Porous β–Tricalcium Phosphate Bone Graft

Abstract

The need for bone repair has increased as the population ages. However, currently, the bone grafts still have some disadvantages, such as low compressive strength and porosity, which limit their use. In order to solve these disadvantages, in this study, the porous beta-tricalcium phosphate (β-TCP) anorganic bone graft were prepared from healthy bovine cancellous bone by cell-free, defat and twice calcinations. X-ray diffraction (XRD) was used to investigate the chemical composition of the bone graft. And the morphology, porosity and mechanical strength of the bone graft were also evaluated. The results showed that most constituent of the bone graft was β-TCP. In addition, the bone graft scaffold exhibited the macro and micro porous structure and the porosity was 57.63%, just as the nature cancellous bone. The compressive strength was 4.47±0.63MPa. Above all, the porous β-TCP anorganic bone graft not only has similar chemical composites as the nature cancellous bone, but also it can effectively retain the porous structure of natural cancellous bone and provides optimal channels for the ingrowth of new bone and blood vessels.Therefore, the porous β-TCP anorganic bone graft is a potential biomaterial in bone tissue engineering.