Preparation and properties of polyvinyl acetal sponge modified by chitosan

Abstract

The polyvinyl acetal sponge modified by chitosan was prepared by adding chitosan/polyvinyl alcohol (PVA) solution during the acetalation reaction of PVA and formaldehyde. The effect of vesicant and chitosan to the pore morphology, water absorption ratio, water absorption rate, expansion time and mechanical properties were studied. The polyvinyl acetal sponge modified by chitosan was used as a hemostatic packing material for the injured rabbit nasal tissue. The hemostatic effect and the healing effect of the modified sponge on the nasal mucosa after nasal surgery were studied. The results indicated that the polyvinyl acetal sponge modified by chitosan has an interconnected pore structure and the wall between large pores also has small pores. The chitosan adhered on the inner surface of the pores. The increased content of vesicant led to an increase in pore diameter, in the water absorption ratio and in expansion time. However, there was only a small change in the water absorption rate and a decrease in tensile strength and compression strength were noted. With an increase in chitosan content, the pore diameter and interconnection of the sponge was reduced. Water absorption ratio, expansion time and water absorption rate decreased, but tensile strength and compression strength improved. Observation of the rabbit nasal tissue after surgical operation suggested that polyvinyl acetal sponge modified by chitosan has an anti-inflammatory, hemostatic and anti-adherent characteristic and could promote the healing and functional recovery of rabbit nasal mucosa.