Abstract
Poly(dimer acid–dodecanedioic acid) P(DA–DDDA) copolymers and poly(dimer acid–tetradecanedioic acid) P(DA–TA) copolymers have been prepared by melt polycondensation of the corresponding mixed anhydride prepolymers. The copolymers were characterized by FT-IR, gel permeation chromatography (GPC), differential scanning calorimetry (DSC), wide-angle X-ray powder-diffraction, and thermogravimetric analysis (TGA). In vitro studies showed that all the copolymers are degradable in phosphate buffer at 37 °C, and leave an oily dimer acid residue after hydrolysis for the copolymers with high content of dimer acid. The release profiles of a hydrophilic model drug, ciprofloxacin hydrochloride, from the copolymers, follow first-order kinetics. All the preliminary results suggested that the copolymers might be potentially used as drug delivery devices.
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